{"id":852,"date":"2026-01-22T15:23:57","date_gmt":"2026-01-22T15:23:57","guid":{"rendered":"https:\/\/sandbox.ins.gov.mz\/?page_id=852"},"modified":"2026-09-21T20:19:41","modified_gmt":"2026-09-21T18:19:41","slug":"programa-doencas-endemicas-de-grande-impacto-sanitario","status":"publish","type":"page","link":"https:\/\/ins.gov.mz\/en\/programas\/programa-doencas-endemicas-de-grande-impacto-sanitario\/","title":{"rendered":"Program for Endemic Diseases of Major Sanitary Impact"},"content":{"rendered":"
<\/div>
\"Esperan\u00e7a<\/div><\/div>
Hope Guimar\u00e3es<\/span><\/span><\/div><\/div>
\n

<\/i> Coordenadora do programa de Doen\u00e7as End\u00e9micas de Grande Impacto Sanit\u00e1rio
\n<\/i> esperancaguimaraes@ins.gov.mz<\/p>\n<\/div><\/div><\/div><\/div><\/div>

\n

 <\/p>\n

Endemic diseases such as HIV, malaria, tuberculosis, and cholera continue to be a burden on public health in the country, presenting high incidence and prevalence, spreading rapidly and causing outbreaks and epidemics. Thus, in order to reduce the burden of these diseases, the PDEGIS was created, which integrates the research, laboratory, surveillance, training, and communication activities carried out by the INS in its thematic area.<\/p>\n

Program Objectives<\/strong><\/p>\n

Investigate, monitor, and evaluate endemic diseases with a major impact on public health.<\/p>\n

This action refers to the investigation of the main transmissible infections for most of the national territory. In line with the institution's scientific strategy, the PDGIS provides support and scientific guidance through:<\/p>\n

    \n
  • Conducting disease prevalence surveys with a significant public health impact;<\/li>\n
  • Implementation and monitoring of sentinel-based and laboratory surveillance systems for major syndromes with epidemic potential;<\/li>\n
  • Implementation of new robust diagnostic, research, and surveillance platforms for major endemic diseases;<\/li>\n
  • Conducting clinical-epidemiological research on major public health conditions to identify key transmission and propagation points of endemic diseases;<\/li>\n
  • Evaluation of new health technologies, including vaccines, for Sexually Transmitted Infections (STIs), urinary tract infections, respiratory infections, and gastrointestinal infections.;<\/li>\n
  • Conducting fundamental biological studies within the scope of endemic diseases to understand the interactions between disease-causing agents and hosts and\/or vectors and the environment.<\/li>\n<\/ul>\n

    Research Areas<\/strong><\/p>\n

    Biomedical Research<\/strong><\/p>\n

    This area is primarily focused on laboratory-based research (also involving fieldwork) with a main focus on the pathogen. This research, on the one hand, comprises fundamental and translational laboratory research, and on the other hand, the bio-molecular aspects of pathogen transmission and population dynamics. These research areas are broken down into five sub-areas:<\/p>\n

      \n
    1. Infectious Disease Bacteriology (PB-BDE):<\/strong> is dedicated to the study of bacteria relevant to public health, their identification, molecular variants, as well as their antimicrobial susceptibility profile. The main bacteria studied in the endemic diseases program include Mycobacterium tuberculosis, Vibrio cholerae, Salmonella spp., Shigella spp., Escherichia coli, Streptococcus spp., Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Treponema pallidum<\/em>, Haemophilus influenzae<\/em> e Klebsiella pneumoniae.<\/em><\/li>\n
    2. Virology of infectious diseases (PB-VDE):<\/strong> It is dedicated to applying cell biology and molecular biology methods in the investigation of viral diseases. This sub-area aims to establish scientific bases for the improvement of diagnosis, treatment, epidemiology, and control of viral diseases. The main viruses studied in the endemic diseases program include human immunodeficiency virus (HIV), human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus (HSV), respiratory syncytial virus (RSV), Influenza, Rotavirus, Adenovirus, Astrovirus, Sapovirus, Norovirus, and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2).<\/li>\n
    3. Human Parasitology (PB-PH)<\/strong> its main focus is the study of malaria caused by Plasmodium spp<\/em>, particularly the Plasmodium falciparum.<\/em> These studies are focused on evaluating new diagnostic methods, molecular characterization of circulating strains, and their association with antimalarial resistance and transmissibility. This sub-area also conducts research activities aimed at improving knowledge of other parasites and fungi of great public health relevance, such as, Trichomonas vaginalis, Cryptosporidium spp., Isospora cayetanensis, Cyclospora cayetanensis<\/em>, Giardia intestinalis, Entamoeba histolytica<\/em> e Cryptococcus neoformans<\/em>.<\/li>\n
    4. Immunology of Tropical Infectious Diseases (PB-IDET):<\/strong> It is dedicated to the multidisciplinary study of immunological processes at the cellular, molecular, and genetic levels and their implications in health and the pathogenesis of infectious diseases. This sub-area also focuses on the interaction between the immune system, the composition of the human microbiota, and the pathogenicity of infectious agents.<\/li>\n
    5. Genetics in Molecular Epidemiology for Health (PB-GEMS):<\/strong> that applies concepts and methods from genetics and molecular biology to the study of endemic diseases of great public health relevance and factors that confer host susceptibility or resistance to such diseases.<\/li>\n<\/ol>\n

      Clinical Research<\/strong><\/p>\n

      Para esta \u00e1rea, o hospedeiro\/paciente \u00e9 o principal foco da pesquisa, sendo estes estudos a aplica\u00e7\u00e3o dos fundamentos cient\u00edficos das pesquisas biom\u00e9dicas. Os campos de pesquisa incluem avalia\u00e7\u00e3o de abordagens para diagn\u00f3stico, preven\u00e7\u00e3o e de tratamento de doen\u00e7as infecciosas com grande import\u00e2ncia para sa\u00fade p\u00fablica, em um determinado paciente. As pesquisas incluem:<\/p>\n

        \n
      1. Ensaios cl\u00ednicos terap\u00eauticos ou profil\u00e1ticos (PC-ECTP):<\/strong> fazem uma avalia\u00e7\u00e3o sistem\u00e1tica de produtos como vacinas, anticorpos ou medicamentos, em volunt\u00e1rios humanos que seguem estritamente as directrizes do m\u00e9todo cient\u00edfico. O objectivo destas pesquisas \u00e9 descobrir ou confirmar os efeitos e\/ou identificar as reac\u00e7\u00f5es adversas ao produto investigado e\/ou estudar a farmacocin\u00e9tica dos ingredientes activos, de forma a determinar sua efic\u00e1cia e seguran\u00e7a. Os principais ensaios cl\u00ednicos incluem avalia\u00e7\u00e3o de vacinas ou outras abordagens profil\u00e1ticas para o HIV, rotav\u00edrus, p\u00f3lio, HPV e SARS-CoV-2; avalia\u00e7\u00e3o de novas abordagens terap\u00eauticas para TB, mal\u00e1ria, HIV e SARS-CoV-2.<\/li>\n
      2. Estudos observacionais do tipo coorte (PC-EOC):<\/strong> investigam os resultados a longo prazo na sa\u00fade de um grupo de pessoas (estudos longitudinais). Nestes estudos, os indiv\u00edduos com um ou mais perfis de exposi\u00e7\u00e3o a doen\u00e7as end\u00e9micas s\u00e3o seguidos para avaliar a incid\u00eancia, progn\u00f3stico e causas da doen\u00e7a, em determinado per\u00edodo de tempo.<\/li>\n
      3. Estudos observacionais do tipo caso-controlo (PC-EOCC):<\/strong> comparam indiv\u00edduos com uma condi\u00e7\u00e3o de sa\u00fade conhecida, neste caso uma doen\u00e7a end\u00e9mica, e aqueles sem ela, para entender por que alguns indiv\u00edduos ficam doentes e outros n\u00e3o.<\/li>\n
      4. Estudos observacionais do tipo transversal (PC-EOT):<\/strong> geralmente usados para comparar grupos em um \u00fanico ponto.<\/li>\n<\/ol>\n

        Public Health Research<\/strong><\/p>\n

        This line includes epidemiological and disease control studies at the human population level. Here, descriptive epidemiological studies of population-wide scope and disease surveillance approaches for endemic diseases with significant health impact are focused. This area includes small and large prevalence surveys of major endemic diseases, such as HIV, malaria, tuberculosis, and recently the novel coronavirus SARS-CoV-2\/COVID-19. This area also includes laboratory-based surveillance, at sentinel sites and community-based, for major syndromes with epidemic potential, with special emphasis on acute respiratory and diarrheal infections.<\/p>\n

        Partners<\/strong><\/p>\n

        The PDEGIS establishes partnerships with national and international institutions with the aim of strengthening the technical-scientific aspects of the INS, through the creation of synergies that lead to the exchange of research experiences with an impact on public health and capacity development. These partnerships not only support the development of program activities but also allow for support in the strategic axes defined by the INS, with a primary emphasis on teaching and education, where students from national universities and technicians of different levels benefit from long-term and short-term scholarships funded by our partners.<\/p>\n

        Below are some of our partners:<\/p>\n

        Nationals<\/strong><\/p>\n

          \n
        • Manhi\u00e7a Health Research Center (CISM)<\/li>\n
        • Eduardo Mondlane University (UEM)<\/li>\n
        • Higher Institute of Health Sciences (ISCISA)<\/li>\n
        • Pedagogical University (UniMaputo)<\/li>\n
        • L\u00fario University (UniL\u00fario)<\/li>\n
        • Universidade Rovuma (UniRovuma)<\/li>\n
        • Elizabeth Glaser Pediatric AIDS Foundation<\/li>\n
        • CDC Global Health \u2013 Mozambique<\/li>\n
        • Mozambique \u2013 Clinton Health Access Initiative<\/li>\n
        • Doctors Without Borders (MSF)<\/li>\n<\/ul>\n

          International<\/strong><\/p>\n

            \n
          • Ludwig Maximilian University of Munich \u2013 (LMU), Alemanha<\/li>\n
          • University of Bordeaux, France<\/li>\n
          • Barcelona Institute for Global Health (ISGlobal), Espanha<\/li>\n
          • The London School of Hygiene & Tropical Medicine (LSHTM), United Kingdom<\/li>\n
          • Institute of Tropical Medicine Antwerp (ITM), Belgium<\/li>\n
          • Institute of Hygiene and Tropical Medicine (IHMT), Portugal<\/li>\n
          • HIV Vaccine Trials Network (HVTN), United States of America<\/li>\n
          • US Military\u2019s HIV Research Program (MHRP), Estados Unidos da Am\u00e9rica<\/li>\n
          • Division of AIDS, National Institutes of Health, United States of America<\/li>\n
          • Karolinska Institute, Sweden<\/li>\n
          • The Public Health Agency of Sweden (Folkh\u00e4lsomyndigheten), Sweden<\/li>\n
          • Oswaldo Cruz Foundation (Fiocruz), Brazil<\/li>\n
          • Federal University of Rio de Janeiro (UFRJ), Brazil<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":812,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-852","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nPrograma de Doen\u00e7as End\u00e9micas de Grande Impacto Sanit\u00e1rio - Instituto Nacional de Sa\u00fade (INS)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ins.gov.mz\/en\/programas\/programa-doencas-endemicas-de-grande-impacto-sanitario\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Programa de Doen\u00e7as End\u00e9micas de Grande Impacto Sanit\u00e1rio - 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